Technological & Scientific Bai Yun Shan, Endless Innovation
Present scientific and technological situation of the company
1. Varieties and size
Guangzhou Baiyunshan Pharmaceutical Co., Ltd. is a big comprehensive pharmaceutical corporation focused on chemical pharmacy. Under its administration, there are totally 9 pharmacy subsidiaries. Guangzhou Baiyunshan Pharmaceutical Co., Ltd and its famous-brand products enjoy a high prestige in society and in medical and pharmaceutical fields.
- It has obtained productions approval documents for over 1700 varieties / specs.
- Main exclusive products: Cefathiamidine, Cefixime, Beeswax, Naoxinqing Tablet, Long-chain Trigyceride, Compound Vitamin U, Matrine Injection, Xiaozhiling Tablet, Cefalexin Effervescent Tablets, Metprolol Tartrate Injection and so on.
- Products won prizes: Ceftriaxone Sodium, Cefradine, Ciprofloxacin, Cefathiamidine, Huoxin Pill, Danhonghuayu Koufye, Compound Dan-shen Tablet, Kouyanqing and so on won progress prize in science and technology of the province and the city, the outstanding products reward? and the medical scientific award.
- Products of famous brands: Amoxicillin sodium, Acetylspiramycin, Xianlisu (Cefathiamidine), Shifusu (Cefixime), Jundezhi (Ceftriaxone Sodium), Cefradine, Trigyceride, Radix Isatidis Grain, Compound Dan-shen Tablet and so on are famous brands in Guanzhou City and Guangdong Province.
- Products with its sales income over RMB 100,000,000: Amoxicillin sodium, Compound Dan-shen Tablet, Qingkainlin Series, Trigyceride Injection Series
- Patent: The company has applied patents for new important products, products with large production such as bolt dissolving peptide mimics LKS-10, Cefathiamidine, Key medium for Cephalosporins, Radix Isatidis Grain, Compound Dan-shen Tablet and so on. In recent years, the company has won over 120 patents. Among them, 5 innovation patents (including Cefathiamidine), 72 out-shape design patents, and 1 practical patent have obtain accreditation.
2. Technical level
The production technology of cephalosporin antibiotics is in advanced level in China. It is the company that firstly developed new synthesizing method for cephalosporin products with GCLE as original material and the company has independent intellectual property for these products. In axenic production technology, dissolve matchmaker's crystallization technology, film technological and so on, out company is in advanced place in China, too. Guangzhou Baiyunshan Pharmaceutical Co., Ltd. is one of the biggest domestic drug producers. It is one of the first one to use capsule and membrane technology in China and the first one to put many products into the market.
3. Talent's team
Presently, Baiyunshan has over 7000 employees. Among them, 1500 are professional technicians, over 600 are middle and high level technicians, and over 30 are doctors and masters. Generally speaking, the company has a high level scientific and technological group in a reasonable structure of primary, middle and high level technical post titles. All these talents are precious treasures for the company to be advanced in technology and science and to keep sustainable development.
4. Innovation system
The innovation system of the company is made up of science and technology committee in strategical & decision-making level, and various develop and research departments in practical operation level. With the company¡¯s general manager as its director, the science and technology committee provides consultation information for decision-making of important scientific and technological items. Baiyunshan Chemical Pharmacy Innovation Center is the first level research and developing organization of the company and the first level innovation center of Guangzhou City. The research institutes or technology developing departments of the 9 subsidiaries of the company are the second level research and developing organizations. The first research and developing organization is responsible for the development of new chemical drugs and important key technologies. It focuses on developing chemical drugs and its new medicament taking the advantage of Cephalosporins, especially on the development of antibiotic oral drugs and injections. Furthermore, it is also responsible for the research and development of cardiovascular drugs and external applications. The second level scientific and technological organizations are responsible for tracking, importing, digesting and absorbing of new products, new technologies and new arts on the base of main products and special products of the company. They are also responsible for solving technological and quality problems met in production.
Development and practice of science and technology
Baiyunshan locates its next development in ¡°Produce best medicine on the base of science and technology, make profits through science and technology and create a scientific and technological Baiyunshan¡±.
1. Develop new drugs with independent intellectual property
To solve the clinic treatment problems of resistance coccus infection, Baiyunshan, cooperating with Shanghai Institute of Pharmaceutical Industry, had developed sole products: Xianlisu (Cefathiamidine for injection use). It is a new type of Cephalosporins and the only one exclusively developed by China and used in clinic treatment. Since its creation, it is warmly welcomed by clinicians and various patients and it sale is increasing every year. Another new dray developed through cooperation with Peking University School of Pharmaceutical Science--- bolt dissolving peptide mimics LKS-10 has been listed as ¡°973¡± important project, China ¡°1035¡± important innovation drug project, China ¡°985¡± great key scientific and technological tackle-key-problem plan, and 2002 Guangzhou important scientific and technical tackle-key-problem project. Its targeted bolt dissolving technology is in advanced place in the world.
2. Combine creation and me-too technology together and energetically develop non-patent drugs
Mimetic creation (me-too) of new drugs is a widely used strategy in the world. It is small in investment, short in period, high in success rate and profitable in market sale. According to calculating, there are totally 102 drug patents expire before 2006. So the company established a chemical drug innovation center, which is also the Chemical Drug Innovation Center of Guangzhou City. The purpose is to track, research and develop in advance the varieties of advantage of non-patent drugs in the market. Once the patent is expired, out company can begin batch production according to market needs. For instance, the me-too variety, the raw material medicine Cefradine, third generation of cephalosporin, has adopted unique synthesizing technics. Its color is light and the content of impurity is low. And it won good social profit and economic profit.
3. Emphasize technological innovation and advocate technological reforming
The continuous innovation of technological flow and method in production procedure can reduce production cost and improve quality of drugs. To Compound Dan-shen Tablet, a product with over RMB 100,000,000 sale income, through using of Soxhelt heat circumfluence extraction technology, low humidity quick dry technology, and water-solubility film coating technology, the product quality is greatly improved. Since 1999, the company has been the greatest domestic Compound Dan-shen Tablet producer for years. Its occupation of domestic market is as high as 28%.
4. Strengthen a secondary development of products
Improve products quality and curative effect through technology development on the base of advanced technologies and equipments. On the one hand, develop new medicines, new compound preparations and new usages. For instance, Compound Dan-shen Tablet can be used to prevent senile dementia. On the other hand, try hard to promote modernization of Chinese medicine and to improve product quality. For instance, the production of Radix Isatidis Grain has its advantages in GAP base construction and fingerprint collection of illustrative plate technology and has won recognition from experts and has applied patent.
Purpose of scientific and technological development
Through combination of production, research, and studying and international collaboration, form an open innovating drug development system with the company¡¯s Innovation Center as its core.
Finish upgrading and replacement of company¡¯s present main products and strategical readjustment of products structure. Ad hoc, realize breakthrough in antibiotic series (with ¦Â---lactarm as its special product) and intermediate patent medicines (with medicines for heard & brain blood vessels as its special products) and develop main products with independent intellectual property. Finally form a core competitive capability with Baiyunshan characteristics.
Establish a perfect scientific and technological talent importing, training, encouraging and managing system to make the research & development organizations of the company be reasonable in structure, highly effective in operation, quickly responsive to market information and be powerful in innovating capability. Make it be a hatch base of the company for scientific and technology achievements, a training base of talents, and an experiment base of innovation systems.
Establish modernized standard second-stage test workshop. Provide mature art and technology for new products. And solve bottle neck problems between lab achievements and industrialization. On the other hand, develop international CRO business.
Establish a sound medicine information network and exert warning function, supporting function to decision-making and acquiring new technology function of information.
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